- Rational ab initio engineering of synthetic bacterial chromosomes
- Functional organization, folding and evolution of chromosomes
- Functional organization of cell nucleus/nucleoid
- Topology, dynamics and spatial development of complex biological networks.
François Képès is a cell biologist. He is currently studying and engineering genome architecture. For this purpose he uses various approaches including molecular, systems and synthetic biology. He leads the "Modelling and Engineering Genome Architecture" (MEGA) team at iSSB.
François Képès is a research director at CNRS. He is the Founding (2002) director of the Epigenomics Project (Genopole), an institute of complex studies. He is the Founding director (2008-10 & 2015-16) of the institute of Systems and Synthetic Biology, at Genopole (iSSB - CNRS, UEVE). He is an invited professor at the Centre for Synthetic Biology and Innovation (CSynBI), at Imperial College London. He is a fellow of the National Academy of Technologies of France.
François Képès is the author of over 110 scientific publications and the editor or author of 20 books and of 13 book chapters. He has organized or chaired 2-7 international scientific events per year, including over 40 in Synthetic Biology since 2005. He is currently a partner, PI or co-PI in several funded Projects. He serves as the editor of four international journals including "Synthetic Biology", as a referee for 19 others, and as an expert advisor for 11 European, North- and South-American and Middle-East funding agencies. He acted as the team leader of the first French iGEM team, that was finalist, won a gold medal, and was awarded the first prize of foundational research at MIT in 2007.