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De novo engineering of biological circuits through in silico evolution

We developed a new strategy for a novel generation of synthetic regulatory networks relying on RNA instead of proteins as it occurs with conventional gene networks. Synthetic RNA molecules detect a small-molecule and transduce the signal into other RNA molecules that could be cascaded and/or combined through RNA-only pathways to finally control the expression of targeted proteins.

De novo engineering of biomolecules and phage-like particles through programmable evolution

We are programming phage and bacteria to "execute" in living cells combinatorial optimisation algorithms with the aim of creating novel biomolecules and antimicrobials. For this, we have developed a new type of directed evolution, which we call "programmable" because of its similarity with the von Neumann architecture.

We are looking for strongly motivated and talented people willing to contribute developing a disruptive methodology to create new molecules and phages different to anything known ("de novo"). In particular, we aim to create a new generation of personalized antimicrobials based on synthetic phages.




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Location - contact


5 rue Henri Desbruères
Genopole Campus 1, Bât. 6

contact (at)

Phone: +33(0)1 69 47 44 30
Fax: +33(0)1 69 47 44 37


To visit us, please follow Genopole access indications.  Once on Genopole campus 1, iSSB is located on the first floor of Building 6, which is the first building to your left as you cross the pedestrian gate, or to your right as you cross the car gate.


Longitude: E 2° 27' 4''
Latitude: N 48° 37' 7''



 GDR Biosynsys 2018, Toulouse, October 21-24, 2018. Registrations are open


 iSSB is pleased to announce the creation of the spin-off Synovance, founded by two former iSSB researchers.

Congratulations to the iGEM 2017 team "Evry-Paris Saclay" that won a Gold Medal at the final world iGEM jamboree. To follow their work, please visit their wiki.

 The spin-off of iSSB Inovactis, founded by two former mSSB students, won the national competition I-Lab 2017 organized each year by the Ministry of Higher Education and Research to encourage the most innovative technologies.

  Based on publications in synthetic biology, an independent study (Nov 2015) found that iSSB ranks 3rd lab in Europe and 9th in the world, despite a comparatively small size.