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Synth-Bio

The synth-bio group works on the design, synthesis and characterization of synthetic regulatory pathways. Our objective is to systematically construct models from scratch, either of synthetic protein, enzyme or nucleic acid parts, or of genetic devices (oscillators, inverters, amplifiers, digital devices, memory units...), taking special care to: the part characterization; the proteomic/transcriptomic analysis of the E. coli chassis and the re-use of that data in simulations to predict the final behaviour. This approach has the advantages of being quantitative, reproducible and it builds from the current knowledge of the rational design of parts and systems. We will take advantage of our automated computational design methodologies that could be later used with other model systems. We will also benefit from the increasingly available high-throughput data in structural and systems biology. We take advantage of MIT's biobrick database to experimentally construct and characterize our designs and we will incorporate back into the software the necessary design specifications that will arise from the experiments.

The design of more complex genetic devices will pose important questions such as the designability of biological networks, the scalability of the assembly of devices, the most appropriate way to model devices from modular components, or the robustness under noises or under evolutionary pressure. Our aim is to address such questions by extending our computational design methodology while working with concrete projects to be experimentally validated. We will work with an E. coli chassis implementing the different types of genetic devices (sensor, regulatory and metabolic) that would arise from the previous projects.

For further details please visit our website

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Location - contact

iSSB
CNRS FRE3561 - UEVE - GENOPOLE 

5 rue Henri Desbruères
Genopole Campus 1, Bât. 6
F-91030 ÉVRY CEDEX, FRANCE

contact (at) issb.genopole.fr

Phone: +33(0)1 69 47 44 30
Fax: +33(0)1 69 47 44 37

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To come, please follow Genopole access indications. On the Genopole campus, iSSB is located at 1st floor of Building 6, placed on your left (if you come by pedestrian entry) or on your right (if your come by vehicle entry).

GPS

Longitude: E 2° 27' 4''
Latitude: N 48° 37' 7''

 


News

  The European Experience 2016!  The teams iGEM Evry-Genopole and iGEM IONIS have organized together a thrilling meeting week-end, gathering students from all Europe who came to Paris and presented their iGEM project.

 The iGEM-Evry-Genopole 2016 team, with his project Let's PLAy! will try to produce a bioplastic ready to be used for biomedical applications and 3D printing. To learn about iGEM-Evry teams hosted by iSSB since 2012, please visit our iGEM webpage.

  Based on publications in synthetic biology, an independent study (Nov 2015) found that iSSB ranks 3rd lab in Europe and 9th in the world, despite a comparatively small size.


 BioSynSys 2016, June 27-29, 2016 in Bordeaux, France

"Genome Architecture in Space and Timeat ICTP, June 20-24, 2016, in Trieste, Italy