Leader: Alfonso Jaramillo
Our lab is developing new technologies (computational and experimental) for the de novo engineering of biomolecules and their interactions (in particular, with the long-term goal of creating synthetic phages as antimicrobials).
De novo engineering of biological circuits through in silico evolution
We developed a new strategy for a novel generation of synthetic regulatory networks relying on RNA instead of proteins as it occurs with conventional gene networks. Synthetic RNA molecules detect a small-molecule and transduce the signal into other RNA molecules that could be cascaded and/or combined through RNA-only pathways to finally control the expression of targeted proteins.
De novo engineering of biomolecules and phage-like particles through programmable evolution
We are programming phage and bacteria to "execute" in living cells combinatorial optimisation algorithms with the aim of creating novel biomolecules and antimicrobials. For this, we have developed a new type of directed evolution, which we call "programmable" because of its similarity with the von Neumann architecture.
We are looking for strongly motivated and talented people willing to contribute developing a disruptive methodology to create new molecules and phages different to anything known ("de novo"). In particular, we aim to create a new generation of personalized antimicrobials based on synthetic phages.
For further details please visit http://synth-bio.org