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We ask a variety of questions such as: 

  • Is there a collective transcriptional scheme in the cell?
  • May the principles ruling this scheme inspire new control algorithms?
  • Do we know enough that we can design from scratch a full synthetic chromosome?
  • Can we characterize the dispensable genome and build a minimal genome?
  • Why duplication and genome redundancy? Can we rationally engineer novel functions?
  • Is there a collective scheme that drives a metabolic control on DNA replication, transcription and genome architecture? 
  • Can we effectively predict the DNA sites where proteins bind?



Location - contact


5 rue Henri Desbruères
Genopole Campus 1, Bât. 6

contact (at)

Phone: +33(0)1 69 47 44 30
Fax: +33(0)1 69 47 44 37


To visit us, please follow Genopole access indications.  Once on Genopole campus 1, iSSB is located on the first floor of Building 6, which is the first building to your left as you cross the pedestrian gate, or to your right as you cross the car gate.


Longitude: E 2° 27' 4''
Latitude: N 48° 37' 7''



Thematic Research School "advances in Systems & Synthetic Biology", aSSB-Evry'18March 19-23, 2018 in Evry.

 iSSB is pleased to announce the creation of the spin-off Synovance, founded by two former iSSB researchers.

Congratulations to the iGEM 2017 team "Evry-Paris Saclay" that won a Gold Medal at the final world iGEM jamboree. To follow their work, please visit their wiki.

 The spin-off of iSSB Inovactis, founded by two former mSSB students, won the national competition I-Lab 2017 organized each year by the Ministry of Higher Education and Research to encourage the most innovative technologies.

  Based on publications in synthetic biology, an independent study (Nov 2015) found that iSSB ranks 3rd lab in Europe and 9th in the world, despite a comparatively small size.