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Teams

Bio-RetroSynth

MEGA

We ask a variety of questions such as: 

  • Is there a collective transcriptional scheme in the cell?
  • May the principles ruling this scheme inspire new control algorithms?
  • Do we know enough that we can design from scratch a full synthetic chromosome?
  • Can we characterize the dispensable genome and build a minimal genome?
  • Why duplication and genome redundancy? Can we rationally engineer novel functions?
  • Is there a collective scheme that drives a metabolic control on DNA replication, transcription and genome architecture? 
  • Can we effectively predict the DNA sites where proteins bind?

 

 

Synth-Bio

De novo engineering of biological circuits through in silico evolution

We developed a new strategy for a novel generation of synthetic regulatory networks relying on RNA instead of proteins as it occurs with conventional gene networks. Synthetic RNA molecules detect a small-molecule and transduce the signal into other RNA molecules that could be cascaded and/or combined through RNA-only pathways to finally control the expression of targeted proteins.

De novo engineering of biomolecules and phage-like particles through programmable evolution

We are programming phage and bacteria to "execute" in living cells combinatorial optimisation algorithms with the aim of creating novel biomolecules and antimicrobials. For this, we have developed a new type of directed evolution, which we call "programmable" because of its similarity with the von Neumann architecture.

We are looking for strongly motivated and talented people willing to contribute developing a disruptive methodology to create new molecules and phages different to anything known ("de novo"). In particular, we aim to create a new generation of personalized antimicrobials based on synthetic phages.

 

 

 

For further details please visit http://synth-bio.org

 

Xenome

Imperatively, such components should be completely hazardless for their surrounding by their inability to genetically spread into existing ecosystems. As the natural genetic code for all life on our planet is solely recognized in the form of DNA and RNA polymers, a robust approach is being development of a truly orthogonal nucleic acid which is chemically distinct from DNA and RNA, but which can harbour structural and/or sequence information that is essential for the viability and phenotype of the cell. Obviously, such a “xeno”-nucleic acid (XNA) will be genetically inert, unless it can be accommodated by artificially evolved enzymes and synthesized from its xeno-nucleotide (XN) precursors. The latter, however, are not present in nature and need to be chemically synthesized and explicitly provided to the cell.


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Location - contact

iSSB
CNRS FRE3561 - UEVE - GENOPOLE 

5 rue Henri Desbruères
Genopole Campus 1, Bât. 6
F-91030 ÉVRY CEDEX, FRANCE

contact (at) issb.genopole.fr

Phone: +33(0)1 69 47 44 30
Fax: +33(0)1 69 47 44 37

iSSBbuildingsmall.jpg

To visit us, please follow Genopole access indications.  Once on Genopole campus 1, iSSB is located on the first floor of Building 6, which is the first building to your left as you cross the pedestrian gate, or to your right as you cross the car gate.

GPS

Longitude: E 2° 27' 4''
Latitude: N 48° 37' 7''

 


News

 The iGEM-Evry 2016 team, with his project Let's PLAy! will try to produce a bioplastic ready to be used for biomedical applications and 3D printing.

  The European Experience 2016!  The teams iGEM Evry and iGEM IONIS have organized together a thrilling meeting week-end, gathering students from all Europe who came to Paris and presented their iGEM project.

 

  Based on publications in synthetic biology, an independent study (Nov 2015) found that iSSB ranks 3rd lab in Europe and 9th in the world, despite a comparatively small size.