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Bio-RetroSynth

ASG: Analytic and Synthetic Genomics

Welcome to the web page of Laurent Janniere's team

We are asking a variety of questions such as:

  • How metabolism controls DNA replication, genome architecture and genome expression?
  • May the mechanisms involve new signalling pathways?
  • May they be geared by metabolite concentrations?
  • May they involve moonlighting activities of metabolic enzymes?
  • Is there a collective scheme that drives these mechanisms?
  • Do transcription factors affect genome architecture?
  • How genome architecture affects transcription?
  • Can we design from this knowledge a powerful synthetic genome from scratch?  

 

 

Xenome

Imperatively, such components should be completely hazardless for their surrounding by their inability to genetically spread into existing ecosystems. As the natural genetic code for all life on our planet is solely recognized in the form of DNA and RNA polymers, a robust approach is being development of a truly orthogonal nucleic acid which is chemically distinct from DNA and RNA, but which can harbour structural and/or sequence information that is essential for the viability and phenotype of the cell. Obviously, such a “xeno”-nucleic acid (XNA) will be genetically inert, unless it can be accommodated by artificially evolved enzymes and synthesized from its xeno-nucleotide (XN) precursors. The latter, however, are not present in nature and need to be chemically synthesized and explicitly provided to the cell.

SysFate

Team leader: Marco Mendoza Parra

https://marcomendozabpn.wixsite.com/sysfate


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Location - contact

iSSB
CNRS UMR8030 - UEVE - CEA - GENOPOLE 

5 rue Henri Desbruères
Genopole Campus 1, Bât. 6
F-91030 ÉVRY CEDEX, FRANCE

contact (at) issb.genopole.fr

Phone: +33(0)1 69 47 44 30
Fax: +33(0)1 69 47 44 37

iSSBbuildingsmall.jpg

To visit us, please follow Genopole access indications.  Once on Genopole campus 1, iSSB is located on the first floor of Building 6, which is the first building to your left as you cross the pedestrian gate, or to your right as you cross the car gate.

GPS

Longitude: E 2° 27' 4''
Latitude: N 48° 37' 7''

 


News

   Congratulations to the iGEM-Evry 2018 team that was nominated for the "best composite part" price, and that won a Gold Medal at the final world iGEM jamboree. To follow their work, please visit their wiki.

 

 The annual spring School on advances in Systems and Synthetic Biology (aSSB) becomes an autumn School, on November 18-22, 2019.

 iSSB is pleased to announce the creation of the spin-off Synovance, founded by two former iSSB researchers.

 The spin-off of iSSB Inovactis, founded by two former mSSB students, won the national competition I-Lab 2017 organized each year by the Ministry of Higher Education and Research to encourage the most innovative technologies.

  Based on publications in synthetic biology, an independent study (Nov 2015) found that iSSB ranks 3rd lab in Europe and 9th in the world, despite a comparatively small size.