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  1. Gasse C, Zaarour M, Noppen S, Abramov M, Marlière P, Liekens S, De Strooper B, Herdewijn P. Modulation of BACE1 activity by chemically modified aptamers.   Chembiochem. 2018, 19(7):754-763. doi: 10.1002/cbic.201700461.
  2. Delépine B, Duigou T, Carbonell P, Faulon JL. RetroPath2.0: A retrosynthesis workflow for metabolic engineers.  Metab Eng. 2018, 45:158-170. doi: 10.1016/j.ymben.2017.12.002.
  3. Koch M, Pandi A, Delépine B, Faulon JL. A dataset of small molecules triggering transcriptional and translational cellular responses. Data Brief. 2018, 17:1374-1378. doi: 10.1016/j.dib.2018.02.061. eCollection 2018 Apr.
  4. Carbonell P, Delépine B, Faulon JL. Extended Metabolic Space Modeling. Methods Mol Biol. 2018, 1671:83-96. doi: 10.1007/978-1-4939-7295-1_6.
  5. Pezo VHassan C, Louis D, Sargueil B, Herdewijn P, Marliere P. Metabolic recruitment and directed evolution of nucleoside triphosphate uptake in Escherichia coli. ACS Synth Biol. 2018, 7(6):1565-1572. doi: 10.1021/acssynbio.8b00048.
  6. Liu C, Cozens C, Jaziri F, Rozenski J, Maréchal A, Dumbre SG, Pezo VMarliere P, Pinheiro VB, Groaz E, Herdewijn P. Phosphonomethyl Oligonucleotides as Backbone Modified Artifi-cial Genetic Polymers.  J Am Chem Soc. 2018, 140:6690-6699. doi: 10.1021/jacs.8b03447.
  7. Trabelsi H, Koch M, Faulon JL. Building a minimal and generalizable model of transcription-factor based biosensors: showcasing flavonoids. Biotechnol Bioeng. 2018, 115:2292-2304. doi: 10.1002/bit.26726.
  8. Jabgunde AM, Jaziri F, Bande O, Froeyen M, Abramov M, Nguyen H, Schepers G, Lescrinier E, Pinheiro VB, Pezo V,Marlière P, Herdewijn P. Methylated nucleobases: Synthesis and evaluation for base pairing in vitro and in vivo. Chemistry 2018, 24:12695-12707. doi: 10.1002/chem.201802304.
  9. Gangwe Nana GY, Ripoll C, Cabin-Flaman A, Gibouin D, Delaune A, Janniere L, Grancher G, Chagny G, Loutelier-Bourhis C, Lentzen E, Grysan P, Audinot JN, Norris V. Division-Based, Growth Rate Diversity in Bacteria. Front Microbiol. 2018, May 11;9:849. doi: 10.3389/fmicb.2018.00849. eCollection 2018.
  10. Nouri H, Monnier AF, Fossum-Raunehaug S, Maciag-Dorszynska M, Cabin-Flaman A, Képès F,Wegrzyn G, Szalewska-Palasz A, Norris V, Skarstad K, Janniere L. Multiple links connect central carbon metabolism to DNA replication initiation and elongation in Bacillus subtilis.  DNA Res. 2018, Sep 26. doi: 10.1093/dnares/dsy031. [Epub ahead of print]
  11. Duigou T, du Lac M, Carbonell P, Faulon JL.  RetroRules: a database of reaction rules for engineering biology. Nucleic Acids Res. 2018, Oct 13. doi: 10.1093/nar/gky940. [Epub ahead of print]
  12. Le Treut G, Képès F, Orland H. A Polymer Model for the Quantitative Reconstruction of Chromosome Architecture from HiC and GAM Data. Biophys J2018 Nov 10. pii: S0006-3495(18)31225-6. doi: 10.1016/j.bpj.2018.10.032. [Epub ahead of print]

  13. de Lorenzo V, Marlière P. The Synthetic Microbiology Caucus: a fresh channel for exploring new ideas, challenging conventional wisdom and fostering community projects.  Microb Biotechnol2018, Oct 25. doi: 10.1111/1751-7915.13331. [Epub ahead of print]
  14. Röthlisberger P, Levi-Acobas F, Sarac I, Marlière P, Herdewijn P, Hollenstein M. Towards the enzymatic formation of artificial metal base pairs with a carboxy-imidazole-modified nucleotide.  J Inorg Biochem2018, Nov 15;191:154-163. doi: 10.1016/j.jinorgbio.2018.11.009. [Epub ahead of print]



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5 rue Henri Desbruères
Genopole Campus 1, Bât. 6

contact (at)

Phone: +33(0)1 69 47 44 30
Fax: +33(0)1 69 47 44 37


To visit us, please follow Genopole access indications.  Once on Genopole campus 1, iSSB is located on the first floor of Building 6, which is the first building to your left as you cross the pedestrian gate, or to your right as you cross the car gate.


Longitude: E 2° 27' 4''
Latitude: N 48° 37' 7''



   Congratulations to the iGEM-Evry 2018 team that was nominated for the "best composite part" price, and that won a Gold Medal at the final world iGEM jamboree. To follow their work, please visit their wiki.


 The annual spring School on advances in Systems and Synthetic Biology (aSSB) becomes an autumn School, on November 18-22, 2019.

 iSSB is pleased to announce the creation of the spin-off Synovance, founded by two former iSSB researchers.

 The spin-off of iSSB Inovactis, founded by two former mSSB students, won the national competition I-Lab 2017 organized each year by the Ministry of Higher Education and Research to encourage the most innovative technologies.

  Based on publications in synthetic biology, an independent study (Nov 2015) found that iSSB ranks 3rd lab in Europe and 9th in the world, despite a comparatively small size.