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  1. Brödel AK, Jaramillo A, Isalan M. Engineering orthogonal dual transcription factors for multi-input synthetic promoters. Nat Commun. 2016, 7:13858. doi: 10.1038/ncomms13858

  2. Le Treut G, Képès F, Orland H. Phase Behavior of DNA in the Presence of DNA-Binding Proteins.  Biophys J. 2016, 110(1):51-62. doi: 10.1016/j.bpj.2015.10.027.
  3. Bande O, Braddick D, Agnello S, Jang M, Pezo V, Schepers G, Rozenski J, Lescrinier E, Marliere P, Herdewijn P. Base pairing involving artificial bases in vitro and in vivo.  Chemical Science, 2016, 7:995–1010  (IF 9.1)
  4. Boldt K, van Reeuwijk J, Lu Q, Koutroumpas K, Nguyen TM, Texier T, (.....), Kepes F, et al.  An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.  Nat Commun., 2016. 7:11491. doi: 10.1038/ncomms11491.
  5. Bouyioukos C, Elati M, Képès F. Analysis tools for the interplay between genome layout and regulation. BMC Bioinformatics, 2016. 17 (Suppl 5):191. doi: 10.1186/s12859-016-1047-0.
  6. Delépine B, Libis V, Carbonell P, Faulon JL.  SensiPath: computer-aided design of sensing-enabling metabolic pathways. Nucleic Acids Res. 2016, 44(W1):W226-31. doi: 10.1093/nar/gkw305.
  7. Bouyioukos C, Bucchini F, Elati M, Képès F.  GREAT: a web portal for Genome Regulatory Architecture Tools. Nucleic Acids Res. 2016. 44(W1):W77-82. doi: 10.1093/nar/gkw384
  8. Mellor J, Grigoras I, Carbonell P, Faulon JL.  Semisupervised Gaussian Process for Automated Enzyme Search.  ACS Synth Biol. 2016, 5(6):518-28. doi: 10.1021/acssynbio.5b00294.
  9. Libis V, Delépine B, Faulon JL.  Expanding Biosensing Abilities through Computer-Aided Design of Metabolic Pathways. ACS Synth Biol. 2016, 5(10):1076-1085.
  10. Pasini M, Fernández-Castané AJaramillo A, de Mas C, Caminal G, Ferrer P. Using promoter libraries to reduce metabolic burden due to plasmid-encoded proteins in recombinant Escherichia coli. New Biotechnol. 2016, 33(1):78-90. doi: 10.1016/j.nbt.2015.08.003
  11. Kushwaha M, Rostain W, Prakash S, Duncan JN, Jaramillo A.  Using RNA as Molecular Code for Programming Cellular Function.  ACS Synth Biol. 2016, 5(8):795-809. doi: 10.1021/acssynbio.5b00297.
  12. Libis V, Delépine B, Faulon JL. Sensing new chemicals with bacterial transcription factors.  Curr Opin Microbiol., 2016, 33:105-12. doi: 10.1016/j.mib.2016.07.006. Review.
  13. Eremeeva E, Abramov M, Margamuljana L, Rozenski J, Pezo V, Marlière P, Herdewijn P.  Chemical Morphing of DNA Containing Four Noncanonical Bases.  Angew Chem Int Ed Engl., 2016, 55(26):7515-9. doi: 10.1002/anie.201601529. (IF 11.7)
  14. Bouyioukos C, Reverchon S, Képès F. From multiple pathogenicity islands to a unique organized pathogenicity archipelago.  Sci Rep., 2016. 6:27978. doi: 10.1038/srep27978.
  15. Taylor AI, Beuron F, Peak-Chew S-Y, Morris EP, Herdewijn P, Holliger P. Nanostructures from synthetic genetic polymers. ChemBioChem, 2016, 17:1107–1110.  (IF 3.1)
  16. Rodrigo G, Prakash S, Cordero T, Kushwaha M, Jaramillo A.  Functionalization of an Antisense Small RNA. J. Mol. Biol. 2016, 428 (5 PtB):889-892. doi: 10.1016/j.jmb.2015.12.022.
  17.  Lioliou E, Fechter P, Caldelari I, Jester BC, Dubrac S, Helfer AC, Boisset S, Vandenesch F, Romby P, Geissmann T.  Various checkpoints prevent the synthesis of Staphylococcus aureus peptidoglycan hydrolase LytM in the stationary growth phase.  RNA Biol. 2016, 22:1-14.
  18.  Spirhanzlova P, Dhorne-Pollet S, Fellah JS, Da Silva C, Tlapakova T, Labadie K, Weissenbach J, Poulain J, Jaffredo T, Wincker P, Krylov V, Pollet N. Construction and characterization of a BAC library for functional genomics in Xenopus tropicalis.  Dev Biol., 2016. May 30. pii: S0012-1606(16)30050-1. [Epub ahead of print]
  19. Cabin-Flaman A, Monnier A-F, Coffinier Y,
 Audinot J-N, Gibouin D, Wirtz T, Boukherroub R,
Migeon H-N, Bensimon A, Jannière L, Ripoll C, Norris V.  Combining conbing and secondary ion mass spectroscopy to study DNA on chips using 13C and 15N labeling. F1000Res. 2016, 5 :1437. Doi :10.12688/f1000research.8361.1.
  20. Bronchain OJ, Chesneau A, Monsoro-Burq AH, Jolivet P, Paillard E, Scanlan TS, Demeneix BA, Sachs LM, Pollet N.  Implication of thyroid hormone signaling in neural crest cells migration: Evidence from thyroid hormone receptor beta knockdown and NH3 antagonist studies.  Mol. Cell. Endocrinol. 2016, Sep 10. pii: S0303-7207(16)30372-0. doi: 10.1016/j.mce.2016.09.007
  21. de Lorenzo V, Marlière P, Solé R. Bioremediation at a global scale: from the test tube to planet Earth.  Microb Biotechnol. 2016, 9(5):618-25. doi: 10.1111/1751-7915.12399.
  22. Sagona AP, Grigonyte AM, MacDonald PR, Jaramillo A. Genetically modified bacteriophages. Integr. Biol., 2016, 8:465-474.
  23. Dinh Thi VH, Coriton O, Le Clainche I, Arnaud D, Gordon SP, Linc G, Catalan P, Hasterok R, Vogel JP, Jahier J, Chalhoub B.  Recreating Stable Brachypodium hybridum Allotetraploids by Uniting the Divergent Genomes of B. distachyon and B. stacei.  PLoS One. 2016, 11(12):e0167171. doi: 10.1371/journal.pone.0167171.
  24. Eremeeva E, Abramov M, Marlière P, Herdewijn P.  The 5-chlorouracil:7-deazaadenine base pair as an alternative to the dT:dA base pair. Org Biomol Chem. 2016, 15(1)168-176.
  25. Trejo D, Khan S, Trebulle P, Elati M.  Networks interrogation for genotype-phenotype study of the yeast diauxic shift. 17th International conference on systems biology, ICSB Proceedings, Barcelona, p56-59, 2016.
  26. Njah H, Jamoussi S, Mahdi W and Elati M.  A Bayesian approach to construct context-specific gene ontology.  Computational Intelligence in Bioinformatics and Computational Biology, IEEE, pp. 1-6, 2016.




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Genopole Campus 1, Bât. 6

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To visit us, please follow Genopole access indications.  Once on Genopole campus 1, iSSB is located on the first floor of Building 6, which is the first building to your left as you cross the pedestrian gate, or to your right as you cross the car gate.


Longitude: E 2° 27' 4''
Latitude: N 48° 37' 7''



   Congratulations to the iGEM-Evry 2018 team that was nominated for the "best composite part" price, and that won a Gold Medal at the final world iGEM jamboree. To follow their work, please visit their wiki.


 The annual spring School on advances in Systems and Synthetic Biology (aSSB) becomes an autumn School, on November 18-22, 2019.

 iSSB is pleased to announce the creation of the spin-off Synovance, founded by two former iSSB researchers.

 The spin-off of iSSB Inovactis, founded by two former mSSB students, won the national competition I-Lab 2017 organized each year by the Ministry of Higher Education and Research to encourage the most innovative technologies.

  Based on publications in synthetic biology, an independent study (Nov 2015) found that iSSB ranks 3rd lab in Europe and 9th in the world, despite a comparatively small size.