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  1. Taylor AI, Pinheiro VB, Smola MJ, Morgunov AS, Peak-Chew S, Cozens C, Weeks KM, Herdewijn P, Holliger P.  Catalysts from synthetic genetic polymers. Nature. 2015, 518(7539):427-430. doi: 10.1038/nature1398
  2. Nicolle R, Radvanyi F, Elati M. COREGNET: reconstruction and integrated analysis of co-regulatory networks. Bioinformatics, 2015, 31(18):3066-3068. doi:10.1093/bioinformatics/btv305
  3. Shen S, Rodrigo G, Prakash S, Majer E, Landrain TE, Kirov B, Daròs JA, Jaramillo A. Dynamic signal processing by ribozyme-mediated RNA circuits to control gene expression. Nucleic Acids Res. 2015, 43(10):5158-5170.
  4. Vouillot L, Thélie A, Pollet N. Comparison of T7E1 and Surveyor Mismatch Cleavage Assays To Detect Mutations Triggered by Engineered Nucleases. G3 (Bethesda). 2015, 5(3):407-415. doi: 10.1534/g3.114.015834.
  5. Bande O, Abu El Asrar R, Braddick D, Dumbre S, Pezo V, Schepers G, Pinheiro VB, Lescrinier E, Holliger P, Marlière P, Herdewijn P. Isoguanine and 5-methyl-isocytosine bases, in vitro and in vivo. Chemistry. 2015, 21(13):5009-5022. doi: 10.1002/chem.201406392.
  6. Bougerol M, Auradé F, Lambert FM, Le Ray D, Combes D, Thoby-Brisson M, Relaix F, Pollet N, Tostivint H. (2015) Generation of BAC Transgenic Tadpoles Enabling Live Imaging of Motoneurons by Using the Urotensin II-Related Peptide (ust2b) Gene as a Driver. PLoS One 2015, 10(2):e0117370. doi: 10.1371/journal.pone.0117370
  7. Colombo BM, Scalvenzi T, Benlamara S, Pollet N. Microbiota and mucosal immunity in amphibians. Front. Immunol. 6:111. doi:10.3389/fimmu.2015.00111
  8. Fehér T, Libis V, Carbonell P, Faulon JL. A Sense of Balance: Experimental Investigation and Modeling of a Malonyl-CoA Sensor in Escherichia coli. Front. Bioeng. Biotechnol. 2015, Apr 8;3:46. doi: 10.3389/fbioe.2015.00046. eCollection 2015.
  9. De S, Groaz E, Margamuljana L, Abramov M, Marlière P, Herdewijn P. Sulfonate derived phosphoramidates as active intermediates in the enzymatic primer-extension of DNA. Org. Biomol. Chem., 2015, 13(13):3950-3962. doi: 10.1039/c5ob00157a.
  10. Rodrigo G, Majer E, Prakash S, Daròs JA, Jaramillo A, Poyatos JF. Exploring the Dynamics and Mutational Landscape of Riboregulation with a Minimal Synthetic Circuit in Living Cells.  Biophys J. 2015, 109(5):1070-1076. doi: 10.1016/j.bpj.2015.07.021.
  11. Lepage T, Képès F, Junier I. Thermodynamics of long supercoiled molecules: insights from highly efficient Monte Carlo simulations. Biophys J. 2015, 109(1):135-143. doi: 10.1016/j.bpj.2015.06.005.
  12. Amos M, Axmann IM, Blüthgen N, de la Cruz F, Jaramillo A, Rodriguez-Paton A, Simmel F.  Bacterial computing with engineered populations.  Philos Trans A Math Phys Eng Sci. 2015, 373(2046). pii: 20140218. doi: 10.1098/rsta.2014.0218.
  13. Gottrand G, Courau T, Thomas-Vaslin V, Prevel N, Vazquez T, Ruocco MG, Lambrecht B, Bellier B, Colombo BM, Klatzmann D. Regulatory T cell development and function are impaired in mice lacking membrane expression of full length ICAM-1. Immunology 2015, Sep 14. doi: 10.1111/imm.12533. [Epub ahead of print]
  14. Picchetti T, Chiquet J, Elati M, Neuvial P, Nicolle R, Birmelé E.  A model for gene deregulation detection using expression data.  BMC Systems Biology. 2015; 9 Suppl 6:S6. PMID: 26679516
  15. Singh V, Braddick D. Recent advances and versatility of MAGE towards industrial applications.  Syst. Synth. Biol. 2015 Dec;9(Suppl 1):1-9. doi: 10.1007/s11693-015-9184
  16. Elati M. From biological network reconstruction to data analysis and visualization, 6th Annual World DNA and Genome Day - Phase B04: Bioinformatics/Computational Tools, Big Data Analysis and Visualization, Nanjing, China, 2015.

Book chapters

  1. Rostain W, Landrain TE, Rodrigo G, Jaramillo A. Regulatory RNA design through evolutionary computation and strand displacement. Methods Mol. Biol. 2015, 1244:63-78. doi: 10.1007/978-1-4939-1878-2_4.
  2. Bouyioukos C, Elati M, Képès F.  Protocols for probing genome architecture of regulatory networks in hydrocarbon and lipid microorganisms. in McGenity, T. J.; Timmis, K. N. and Nogales Fernandez, B. (Eds.) Hydrocarbon and Lipid Microbiology Protocols, Springer Protocols Handbooks, DOI 10.1007/8623_2015_92, © Springer-Verlag Berlin Heidelberg 2015.
  3. Hassall J, MacDonald P, Cordero T, Rostain W, Jaramillo A. Design and Characterization of Topological Small RNAs. Methods Mol. Biol.. 2015; 1316:149-167. doi: 10.1007/978-1-4939-2730-2_13.


Location - contact


5 rue Henri Desbruères
Genopole Campus 1, Bât. 6

contact (at)

Phone: +33(0)1 69 47 44 30
Fax: +33(0)1 69 47 44 37


To visit us, please follow Genopole access indications.  Once on Genopole campus 1, iSSB is located on the first floor of Building 6, which is the first building to your left as you cross the pedestrian gate, or to your right as you cross the car gate.


Longitude: E 2° 27' 4''
Latitude: N 48° 37' 7''



   Congratulations to the iGEM-Evry 2018 team that was nominated for the "best composite part" price, and that won a Gold Medal at the final world iGEM jamboree. To follow their work, please visit their wiki.


 The annual spring School on advances in Systems and Synthetic Biology (aSSB) becomes an autumn School, on November 18-22, 2019.

 iSSB is pleased to announce the creation of the spin-off Synovance, founded by two former iSSB researchers.

 The spin-off of iSSB Inovactis, founded by two former mSSB students, won the national competition I-Lab 2017 organized each year by the Ministry of Higher Education and Research to encourage the most innovative technologies.

  Based on publications in synthetic biology, an independent study (Nov 2015) found that iSSB ranks 3rd lab in Europe and 9th in the world, despite a comparatively small size.