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  1. Fehér T, Planson AG, Carbonell P, Fernández-Castané A, Grigoras I, Dariy E, Perret A, Faulon JL. Validation of RetroPath, a computer-aided design tool for metabolic pathway engineering.  Biotechnol J. 2014, 9(11):1446-1457. doi: 10.1002/biot.201400055.
  2. Scalvenzi T, Pollet N. Insights on genome size evolution from a miniature inverted repeat transposon driving a satellite DNA.  Mol Phylogenet Evol. 2014, 81C:1-9.  doi: 10.1016/j.ympev.2014.08.014.
  3. Plouhinec JL, Roche DD, Pegoraro C, Figueiredo AL, Maczkowiak F, Brunet LJ, Milet C, Vert JP, Pollet N, Harland RM, Monsoro-Burq AH.  Pax3 and Zic1 trigger the early neural crest gene regulatory network by the direct activation of multiple key neural crest specifiers. Dev Biol. 2014, 386(2):461-472.
  4. Rodrigo G, Jaramillo A. RiboMaker: computational design of conformation-based riboregulation. Bioinformatics, 2014, 30(17):2508-2510 doi:10.1093/bioinformatics/btu335
  5. Carbonell P, Parutto P, Baudier C, Junot C, Faulon JL. Retropath: automated pipeline for embedded metabolic circuits. ACS Synthetic Biology, 2014, 3(8):565-577. doi: 10.1021/sb4001273
  6. Parutto P, Le Goff L, Léger H, Mercy G, van der Kouwe E, Chhun A, Baudu B, Guillocheau G, Amiot F, Ujéda L, Rostain W, Pauthenier C, Cerisy T, Pollet N, Tolonen A, Jaramillo A. Characterization and modeling of an iron-sensitive system in Escherichia coli. In : Proceedings of the Evry Spring School on advances in Systems and Synthetic Biology. (Eds. Amar P, Képès F, Norris V.), EDP Sciences, 2014, p107-118.
  7. Winterhalter C, Nicolle R, Louis A, To C, Radvanyi F, Elati M. PEPPER: Cytoscape app for Protein complex Expansion using Protein-Protein intERaction networks. Bioinformatics, 2014, 30(23):3419-3420.
  8. Pauthenier C, Faulon JL. PrecisePrimer: an easy to use webserver for designing PCR primers for DNA library cloning and DNA Shuffling. Nucleic Acids Research, 2014, Jul;42(Web Server issue):W205-9. doi: 10.1093/nar/gku393.
  9. Fernandez-Castane A, Feher T, Carbonell P, Pauthenier C, Faulon JL. Computer-aided design for metabolic engineering. J. of Biotechnol., 2014, 192 Pt B:302-13. pii: S0168-1656(14)00159-X.
  10. Carbonell P, Parutto P, Herisson J, Pandit S, Faulon JL. XTMS: Pathway Design in an eXTended Metabolic Space. Nucleic Acids Research, 2014, Jul;42(Web Server issue):W389-94. doi: 10.1093/nar/gku362.
  11. Chebil I, Nicolle R, Santini G, Rouveirol C, Elati M. Hybrid method inference for the construction of cooperative regulatory network in human. IEEE transactions on nanobioscience, 2014, 13(2):97-103.
  12. Pezo V, Schepers G, Lambertucci C, Marlière P, Herdewijn P. Probing Ambiguous Base-Pairs by Genetic Transformation with XNA Templates. ChemBioChem 2014, 15(15):2255-2258. NDOI: 10.1002/cbic.201402226.
  13. De S, Groaz E, Maiti M, Pezo V, Marlière P, Herdewijn P. Synthesis of new biocarrier-nucleotide systems for cellular delivery in bacterial auxotrophic strains. Tetrahedron 2014, 70:8843-8851.
  14. Carbonell P, Trosset JY. Overcoming drug resistance through in silico prediction.  Drug Discov Today Technol. 2014, 11:101-107.
  15. Almelli T, Nuel G, Bischoff E, Aubouy A, Elati M, Wang CW, Dillies MA, Copée JY, Nko Ayissi G, Basco LK, Rogier C, Tuikue Ndam N , Deloron P , Tahar R . Differences in gene transcriptomic pattern of Plasmodium falciparum in children with cerebral malaria and asymptomatic carriers. PLoS One, 2014, 9:e114401.
  16. Koutroumpas K, van Dam TJP, Toedt G, Lu Q, van Reeuwijk J, Boldt K, Ueffing M, Gibson T, Russell R, Roepman R, Huynen M, Elati M, Képès F. A systems biology approach towards the prediction of ciliopathy mechanisms, Conference article, in CILIA2014, Paris, France, November 18-21, 2014.
  17. Delépine B, Carbonell P, Faulon JL. XTMS in Action: Retrosynthetic Design in the Extended Metabolic Space of Heterologous Pathways for High-Value Compounds.  In Computational Methods in Systems Biology - 12th International Conference, CMSB 2014, Proceedings.  Manchester, UK, Nov. 17-19, 2014, p256-259.


Book Chapters

  1. Vouillot L, Thelie A, Scalvenzi T, Pollet N. Genomics and genome engineering in Xenopus. in " Xenopus Development" , Kloc M. and Kubiak J.Z.  (eds), John Wiley & Sons. Vol 20, p383-401, 2014.
  2. Elati M, To C, Bouyioukos C. Evolutionary computation for pattern recognition-based inference of functional biological circuits. In book "Pattern Recognition in Computational Molecular Biology: Techniques and Approaches", M. Elloumi, Costas S. IIiopouos, Jason T. L. Wang and A. Y. Zomaya (Eds), Wiley, 2014
  3. Bouyioukos C, Elati  M, Képès F. Genome regulatory and architecture analysis Tools. In "Protocols for Hydrocarbon Microbiology, Higher structure genomic organization", vol 8,  K. Timmis, T. McGenity (Eds), Springer Protocols Series, in press, 2014
  4. Carbonell P, Feher T, Grigoras I, Faulon JL. RetroPath: Retrosynthesis design of metabolic pathways. Proceedings of the Evry Spring School on advances in Systems and Synthetic Biology. (Eds. Amar P, Képès F, Norris V.), EDP Sciences, 2014, p49-56
  5. Bouyioukos C, Elati M, Kepes F. GREAT: Genome REgulatory and Architecture analysis Tools. Proceedings of the Evry Spring School on advances in Systems and Synthetic Biology. (Eds. Amar P, Képès F, Norris V.), EDP Sciences, 2014, p39-48.
Location - contact


5 rue Henri Desbruères
Genopole Campus 1, Bât. 6

contact (at)

Phone: +33(0)1 69 47 44 30
Fax: +33(0)1 69 47 44 37


To visit us, please follow Genopole access indications.  Once on Genopole campus 1, iSSB is located on the first floor of Building 6, which is the first building to your left as you cross the pedestrian gate, or to your right as you cross the car gate.


Longitude: E 2° 27' 4''
Latitude: N 48° 37' 7''



   Congratulations to the iGEM-Evry 2018 team that was nominated for the "best composite part" price, and that won a Gold Medal at the final world iGEM jamboree. To follow their work, please visit their wiki.


 The annual spring School on advances in Systems and Synthetic Biology (aSSB) becomes an autumn School, on November 18-22, 2019.

 iSSB is pleased to announce the creation of the spin-off Synovance, founded by two former iSSB researchers.

 The spin-off of iSSB Inovactis, founded by two former mSSB students, won the national competition I-Lab 2017 organized each year by the Ministry of Higher Education and Research to encourage the most innovative technologies.

  Based on publications in synthetic biology, an independent study (Nov 2015) found that iSSB ranks 3rd lab in Europe and 9th in the world, despite a comparatively small size.