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  1. Boistel R, Aubin T, Cloetens P, Peyrin F, Scotti T, Herzog P, Gerlach J, Pollet N, Aubry J-F.  How minute sooglossid frogs hear without a middle ear. Proc. Natl. Acad. Sci. 2013, 110(38):15360-15364.    doi: 10.1073/pnas.1302218110
  2. Elati M, Nicolle R, Junier I, Fernández D, Fekih R, Font J, Képès F. PreCisIon: PREdiction of CIS-regulatory elements improved by gene's positION.  Nucleic Acids Res. 2013, 41(3):1406-1415.
  3. Joo J, Plimpton SJ, Faulon JL. Statistical Ensemble Analysis for Simulating Extrinsic Noise-driven Response in NF-kappaB Signaling Network. BMC Systems Biology, 2013, 7:45.
  4. Rodrigo G, Landrain TE, Shen S, Jaramillo A. A new frontier in synthetic biology: Automated design of small RNA devices in bacteria. Trends in Genetics 2013, 29:529-536.  Doi: 10.1016/j.tig.2013.06.005
  5. Carrera J, Jaramillo A.  Automated design of bacterial genome sequences. BMC Systems Biology 2013, 7:108.    Doi: 10.1186/1752-0509-7-108
  6. Rodrigo G, Jaramillo A.  AutoBioCAD: Full bio-design automation of genetic circuits. ACS Synthetic Biology 2013, 2(5):230-236. doi: 10.1021/sb300084h
  7. Rodrigo G, Landrain TE, Majer E, Daròs JA, Jaramillo A. Full design automation of multi-state RNA devices to program gene expression using energy-based optimization. PLOS Comp. Biol. 2013, 9: e1003172. doi:10.1371/journal.pcbi.1003172
  8. Pauthenier C, Carbonell P, Faulon JL. La conception rationnelle de ferments biologiques : comment concevoir un micro-organisme pour produire un composé chimique spécifique. l'Actualité Chimique, 2013, 375:30-36.
  9. Suárez-Diez M, Pujol AM, Matzapetakis M, Jaramillo A, Iranzo O.  Computational protein design with electrostatic focusing and experimental characterization of a conditionally folded helical protein domain with a reduced amino acid alphabet. Biotechnology J. 2013, 8:855-864. doi: 10.1002/biot.201200380.
  10. Pezo V, Louis D, Guérineau V, Le Caer JP, Gaillon L, Mutzel R, Marlière P. A metabolic prototype for eliminating tryptophan from the genetic code.  Sci Rep. 2013, 3:1359.
  11. Rannou O, Lechatelier E, Larson M, Nouri H, Dalmais B, Laughton C, Janniere L, Soultanas P.  Functional interplay of DnaE polymerase, DnaG primase and DnaC helicase within a ternary complex, and primase to polymerase hand-off during lagging strand DNA replication in Bacillus subtilis. Nucleic Acids Res. 2013, 41:5303-5320.
  12. Dhorne-Pollet S, Thélie A, Pollet N. Validation of novel reference genes for RT-qPCR studies of gene expression in Xenopus tropicalis during embryonic and post-embryonic development. Dev. Dyn. 2013, 242(6):709-717.
  13. Carbonell P, Carlsson L, Faulon JL. Stereo signature molecular descriptor.  J. Chem. Inf. Model. 2013, 53(4):887-897.
  14. Rodrigo G, Kirov B, Shen S, Jaramillo A. Theoretical and experimental analysis of the forced LacI-AraC oscillator with a minimal gene regulatory model. Chaos 2013, 23(2):025109. doi: 10.1063/1.4809786.
  15. Pezo V, Liu FW, Abramov M, Froeyen M, Herdewijn P, Marlière P. Binary Genetic Cassettes for Selecting XNA-Templated DNA Synthesis In Vivo.  Angew Chem. Int. Ed. Engl. 2013, 52(31):8139-8143. doi: 10.1002/anie.201303288.
  16. Martiny VY, Carbonell P, Lagorce D, Villoutreix BO, Moroy G, Miteva MA. In Silico Mechanistic Profiling to Probe Small Molecule Binding to Sulfotransferases. PLoS ONE 2013, 8(9): e73587. doi:10.1371/journal.pone.0073587
  17. Rodrigo G, Elena SF.  MicroRNA Precursors Are Not Structurally Robust but Plastic. Genome Biol. Evol. 2013; 5(1): 181–186.
  18. Jaghoori MM, Jongmans STQ, de Boer F, Peironcely J, Faulon JL, Reijmers T, Hankemeier T. PMG: Multi-core metabolite identification. Electronic Notes in Theoretical Computer Science, 2013, 299: 53-60.
  19. Trosset JY, Carbonell P. Synergistic synthetic biology: units in concert. Frontiers in Bioeng. Biotechnol. 2013, 1:11.
  20. Xu S, Ying H, Carbonell P, Hu J, Lee C, Wu W. Fuzzy logic applications in control theory and systems biology. Advances in Fuzzy Systems, 504728, 2013
  21. Kepes F.  [Scientific and technological conditions of the emergence of synthetic biology]. Med Sci (Paris). 2013, Spec No 2:13-15.
  22. Pauthenier C, Faulon JL. Ingénierie métabolique et biologie de synthèse. Technique de l’ingénieur, article BIO800, nov. 2013.
  23. Pauthenier, C, Faulon JL. Les composés produits par ingénierie métabolique. Technique de l’ingénieur, article BIO801, nov. 2013.
  24. To C, Elati M. A parallel genetic programming for single class classification. In Genetic and evolutionary computation (GECCO), ACM Companion, pp 1579-1586, 2013
  25. Chebil I, Elati M, Santini G, Rouveirol C. SETNET: Ensemble Method techniques for Learning Regulatory Networks. In Machine Learning and Applications (ICMLA), IEEE, vol.1, pp.34-39, 2013
  26. Elati M, To C, Nicolle R. Multi-objective optimization for relevant sub-graph extraction. Learning and Intelligent OptimizatioN (LION), LNCS, pp 104-109, 2013

Book Chapters

  1. Carbonell P, Planson AG, Faulon JL.  Retrosynthetic design of heterologous pathways.  In Systems Metabolic Engineering, Methods Mol Biol.  2013; 985:149-173.
  2. Sinzelle L, Pollet N. Designing nonviral targeted integrating vectors for genome engineering in vertebrates. In Site directed insertion of transgenes. Ed. Springer Berlin/Heidelberg. Vol. 23, p41-67, 2013.

Location - contact


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Genopole Campus 1, Bât. 6

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Phone: +33(0)1 69 47 44 30
Fax: +33(0)1 69 47 44 37


To visit us, please follow Genopole access indications.  Once on Genopole campus 1, iSSB is located on the first floor of Building 6, which is the first building to your left as you cross the pedestrian gate, or to your right as you cross the car gate.


Longitude: E 2° 27' 4''
Latitude: N 48° 37' 7''



   Congratulations to the iGEM-Evry 2018 team that was nominated for the "best composite part" price, and that won a Gold Medal at the final world iGEM jamboree. To follow their work, please visit their wiki.


 The annual spring School on advances in Systems and Synthetic Biology (aSSB) becomes an autumn School, on November 18-22, 2019.

 iSSB is pleased to announce the creation of the spin-off Synovance, founded by two former iSSB researchers.

 The spin-off of iSSB Inovactis, founded by two former mSSB students, won the national competition I-Lab 2017 organized each year by the Ministry of Higher Education and Research to encourage the most innovative technologies.

  Based on publications in synthetic biology, an independent study (Nov 2015) found that iSSB ranks 3rd lab in Europe and 9th in the world, despite a comparatively small size.