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  1. Rodrigo G, Landrain TE, Jaramillo A. De novo automated design of small RNA circuits for engineering synthetic riboregulation in living cells. Proc. Natl. Acad. Sci. USA. 2012,  109(38):15271-15276.
  2. Carrera J, Elena SF, Jaramillo A. Computational design of genomic transcriptional networks with adaptation to varying environments. Proc. Natl. Acad. Sci. USA. 2012,  109(38):15277-15282.
  3. Carbonell P, Fichera D, Pandit SB, Faulon JL. Enumerating metabolic pathways for the production of heterologous target chemicals in chassis organisms. BMC Syst. Biol., 2012, 6(1):10.
  4. Planson AG, Carbonell P, Grigoras I, Faulon JL.  A retrosynthetic biology approach to therapeutics: from conception to delivery.  Curr. Opin. Biotechnol., 2012, 23(6):948-956.
  5. Planson AG, Carbonell P, Paillard E, Pollet N, Faulon JL. Compound toxicity screening and structure-activity relationship modeling in Escherichia coli.  Biotechnol. Bioeng., 2012, 109(3):846-850.
  6. Peironcely JE, Rojas-Chertó M, Fichera D, Reijmers T, Coulier L, Faulon JL, Hankemeier T.  OMG: open molecule generator. J. Cheminform., 2012, 4(1):21.
  7. Giraut A, Abu El-Asrar R, Marlière P, Delarue M, Herdewijn P. 2'-Deoxyribonucleoside Phosphoramidate Triphosphate Analogues as Alternative Substrates for E. coli Polymerase III.  Chembiochem., 2012, 13(16):2439-2444.
  8. Herdewijn P, Marlière P. Redesigning the leaving group in nucleic acid polymerization.  FEBS Lett., 2012, 586(15):2049-2056.
  9. Pinheiro VB, Taylor AI, Cozens C, Abramov M, Renders M, Zhang S, Chaput JC, Wengel J, Peak-Chew SY, McLaughlin SH, Herdewijn P, Holliger P. Synthetic genetic polymers capable of heredity and evolution. Science, 2012, 336(6079):341-344.
  10. Maiti M, Siegmund V, Abramov M, Lescrinier E, Rosemeyer H, Froeyen M, Ramaswamy A, Ceulemans A, Marx A, Herdewijn P.  Solution Structure and Conformational Dynamics of Deoxyxylonucleic Acids (dXNA): An Orthogonal Nucleic Acid Candidate.  Chemistry, 2012, 18:869-879.
  11. Rodrigo G, Carrera J, Landrain TE, Jaramillo A.  Perspectives on the automatic design of regulatory systems for synthetic biology.  FEBS Lett., 2012, 586(15):2037-2042.
  12. Carrera J, Fernández Del Carmen A, Fernández-Muñoz R, Rambla JL, Pons C, Jaramillo A, Elena SF, Granell A. Fine-tuning tomato agronomic properties by computational genome redesign. PLoS Comput. Biol., 2012, 8(6):e1002528. doi: 10.1371/journal.pcbi.1002528.
  13. Junier I, Dale RK, Hou C, Képès F, Dean A.  CTCF-mediated transcriptional regulation through cell type-specific chromosome organization in the β-globin locus.  Nucleic Acids Res., 2012, 40(16):7718-7727.
  14. Kepes F, Jester BC, Lepage T, Rafiei N, Rosu B, Junier I. The layout of a bacterial genome. FEBS Lett. 2012, 586(15):2043-2048.
  15. Junier I, Hérisson J, Kepes F. Genomic Organization of Evolutionarily Correlated Genes in Bacteria: Limits and Strategies.  J Mol Biol., 2012, 19(5):369-386.
  16. Maciąg-Dorszyńska M, Ignatowska M, Jannière L, Węgrzyn G, Szalewska-Pałasz A.  Mutations in central carbon metabolism genes suppress defects in nucleoid position and cell division of replication mutants in Escherichia coli.  Gene, 2012, 503(1):31-35.
  17. Jester BC, Romby P, Lioliou E. When ribonucleases come into play in pathogens: a survey of gram-positive bacteria. Int. J. Microbiol., 2012, 2012:592196
  18. Sinzelle L, Thuret R, Hwang HY, Herszberg B, Paillard E, Bronchain OJ, Stemple DL, Dhorne-Pollet S, Pollet N.  Characterization of a novel Xenopus tropicalis cell line as a model for in vitro studies. Genesis, 2012, 50:316-324.
  19. Tempel S, Pollet N, Tahi F.  ncRNAclassifier: a tool for detection and classification of transposable element sequences in RNA hairpins. BMC Bioinformatics, 2012, 13(1):246.
  20. Gilchrist MJ, Pollet N. Databases of gene expression in Xenopus development. Methods Mol. Biol., 2012, 917:319-345.
  21. Parain K, Mazurier N, Bronchain OJ, Borday C, Cabochette P, Chesneau A, Colozza G, el Yakoubi W, Hamdache J, Gilchrist M, Pollet N, Perron M.  A large scale screen for neural stem cell markers in Xenopus retina. Developmental Neurobiology, 2012, 72(4):491-506.
  22. Nicolle R, Elati M, Radvanyi F. Network transformation of gene expression for feature extraction. Machine Learning and Applications (ICMLA), IEEE vol 1: pp 108-113, 2012.


Book chapters

  1. Misra M, Martin S, Faulon JL. Graphs: flexible representations of molecular structures and biological network. In Computational Approaches in Cheminformatics and Bioinformatics, (R. Guha and A. Bender Eds.) John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118131411.ch6, 2012.
                Location - contact

                CNRS UMR8030 - UEVE - CEA - GENOPOLE 

                5 rue Henri Desbruères
                Genopole Campus 1, Bât. 6
                F-91030 ÉVRY CEDEX, FRANCE

                contact (at)

                Phone: +33(0)1 69 47 44 30
                Fax: +33(0)1 69 47 44 37


                To visit us, please follow Genopole access indications.  Once on Genopole campus 1, iSSB is located on the first floor of Building 6, which is the first building to your left as you cross the pedestrian gate, or to your right as you cross the car gate.


                Longitude: E 2° 27' 4''
                Latitude: N 48° 37' 7''



                   Congratulations to the iGEM-Evry 2018 team that was nominated for the "best composite part" price, and that won a Gold Medal at the final world iGEM jamboree. To follow their work, please visit their wiki.


                 The annual spring School on advances in Systems and Synthetic Biology (aSSB) becomes an autumn School, on November 18-22, 2019.

                 iSSB is pleased to announce the creation of the spin-off Synovance, founded by two former iSSB researchers.

                 The spin-off of iSSB Inovactis, founded by two former mSSB students, won the national competition I-Lab 2017 organized each year by the Ministry of Higher Education and Research to encourage the most innovative technologies.

                  Based on publications in synthetic biology, an independent study (Nov 2015) found that iSSB ranks 3rd lab in Europe and 9th in the world, despite a comparatively small size.