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  1. Marlière P, Patrouix J, Döring V, Herdewijn P, Tricot S, Cruveiller S, Bouzon M, Mutzel R.  Chemical evolution of a bacterium's genome.  Angew Chem. Int. Ed. Engl. 2011, 50(31):7109-7114.
  2. Carrera J, Rodrigo G, Singh V, Kirov B, Jaramillo A.  Empirical model and in vivocharacterization of the bacterial response to synthetic gene expression show that ribosome allocation limits growth rate. Biotechnol. J. 2011, 6:773-783.
  3. Jaramillo A, Faulon JL. Synthetic Biology - applying new paradigms at the interface of fundamental research and innovation. Biotechnol. J. 2011, 6:766-767.
  4. Rodrigo G, Jaramillo A, Blazquez MA.  Integral control of plant gravitropism through the interplay of hormonal signaling and gene regulation. Biophys. J. 2011, 101:757-763.
  5. Rodrigo G, Carrera J, Jaramillo A.  On the designability of synthetic regulatory networks. Nucl. Acids Res. 2011, 39: e138.
  6. Cabin-Flaman A, Monnier AF, Coffinier Y, Audinot JN, Gibouin D, Wirtz T, Boukherroub R, Migeon HN, Bensimon A, Jannière L, Ripoll C, Norris V.  Combed single DNA molecules imaged by secondary ion mass spectrometry.  Anal. Chem. 2011, 83(18):6940-6947.
  7. Maciąg M, Nowicki D, Jannière L, Szalewska-Pałasz A, Węgrzyn G.  Genetic response to metabolic fluctuations: correlation between central carbon metabolism and DNA replication in Escherichia coli.  Microb. Cell Fact. 2011, 10:19.
  8. Sinzelle L, Carradec Q, Paillard E, Bronchain OJ, Pollet N.  Characterization of a Xenopus tropicalis Endogenous Retrovirus with Developmental and Stress-Dependent Expression. J. Virol. 2011, 85:2167-2179.
  9. Pegoraro C, Pollet N, Monsoro-Burq AH.  Tissue-specific expression of Sarcoplasmic/Endoplasmic Reticulum Calcium ATPases (ATP2A/SERCA) 1, 2, 3 during Xenopus laevis development. Gene Expr. Patterns 2011, 11:122-128.
  10. Demattei M-V, Hedhili S, Sinzelle L, Bressac C, Casteret S, Moiré N, Cambefort J, Thomas X, Pollet N, Gantet P, Bigot Y.  Nuclear Importation of Mariner Transposases among Eukaryotes: Motif Requirements and Homo-Protein Interactions. PLoS ONE 2011, 6(8):e23693. doi:10.1371/journal.pone.0023693
  11. Boistel R, Aubin T, Cloetens P, Langer M, Gillet B, Josset P, Pollet N, Herrel A.  Whispering to the Deaf: Communication by a Frog without External Vocal Sac or Tympanum in Noisy Environments. PLoS ONE 2011, 6(7):e22080. doi:10.1371/journal.pone.0022080
  12. Planson AG, Carbonell P, Grigoras I, Faulon JL.  Engineering antibiotic production and overcoming bacterial resistance. Biotechnol. J. 2011, 6:812-825. Review
  13. Misra M, Andrienko D, Baumeier B, Faulon JL, von Lilienfeld OA.  Toward Quantitative Structure-Property Relationships for Charge Transfer Rates of Polycyclic Aromatic Hydrocarbons. J. of Chem. Theory and Computation, 2011, 7: 2549-2555.
  14. Carbonell P, Lecointre G, Faulon JL. Origins of specificity and promiscuity in metabolic networks. J. of Biol. Chem. 2011. 286:43994-44004.
  15. Carbonell P, Planson AG, Fichera D, Faulon JL. A retrosynthetic biology approach to metabolic pathway design for therapeutic production. BMC Systems Biology, 2011, 5:122.
  16. Carbonell P, Faulon JL.  Using retrosynthetic biology to design metabolic pathways for therapeutics production. In SB5.0: the Fifth International Meeting on Synthetic Biology, Stanford University, Stanford (USA), 2011.
  17. Glykys DJ, Szilvay GR, Tortosa P, Suarez M, Jaramillo A, Banta S.  Pushing the Limits of Automatic Computational Protein Design: Design, Expression, and Characterization of a Large Synthetic Protein based on a Fungal Laccase Scaffold. Systems and Synthetic Biology 2011, 5:45-58.
  18. Camsund D, Lindblad P, Jaramillo A.  Genetically Engineered Light Sensors for Control of Bacterial Gene Expression. Biotechnol. J. 2011, 6:826-836.
  19. Rodrigo G, Carrera J, Jaramillo A, Elena SF. Optimal viral strategies for bypassing RNA silencing. J.R. Soc. Interface, 2011, 8:257-268.
  20. Yang S, Froeyen M, Lescrinier E, Marlière P, Herdewijn P.  3-Phosphono-L-alanine as pyrophosphate mimic for DNA synthesis using HIV-1 reverse transcriptase. Org.  Biomol. Chem. 2011, 9:111-119.
  21. Jang M, Lin Y, De Jonghe S, Gao L, Vanderhoydonck B, Froeyen M, Rozenski J, Herman J, Louat T, Van Belle K, Waer M, Herdewijn P.  Discovery of 7-N-Piperazinylthiazolo[5,4-d]pyrimidine analogues as a novel class of immunosuppressive agents with in vivo biological activity. J. Med. Chem. 2011, 54:655-668.
  22. Chavain N, Herdewijn P. 2 '-Deoxy-2 '-alpha-C-(hydroxymethyl)adenosine as Potential anti-HCV Agent. Eur. J. Org. Chem. 2011, 6:1140-1147.
  23. Huang Q, Herdewijn P.  Synthesis of (E)-3′-phosphonoalkenyl modified nucleoside phosphonates via a highly stereoselective olefin cross-metathesis reaction. J. Org. Chem.2011, 76:3742-3753.
  24. Kirkilionis M, Képès F.  Introduction to special issue ECCS'09. Theory in Biosciences 2011, 130:153.
  25. Képès F.  Biologie synthétique et intégrative. C. R. Chimie, 2011, 14:420-423.
  26. Norris V, Zemirline A, Amar P, Audinot JN, Ballet P, Ben-Jacob E, Bernot G, Beslon G, Cabin A, Fanchon E, Giavitto JL, Glade N, Greussay P, Grondin Y, Foster JA, Hutzler G, Jost J, Kepes F, Michel O, Molina F, Signorini J, Stano P, Thierry AR.  Computing with bacterial constituents, cells and populations: from bioputing to bactoputing.  Theory Biosci. 2011, 130(3):211-228.
  27. Elati M, Fekih R, Nicolle R, Junier I, Herisson J, Képès F. Boosting binding sites prediction using gene’s positions. Algorithms in Bioinformatics (WABI), LNCS, 2011, 6833:92-103.


Book chapters

  1. Képès F.  Morphodynamics of secretory endomembranes. In Morphogenesis - Origins of patterns and shapes (eds. Bourgine & Lesne) 2011, p. 119-141. Springer: complexity, New York. ISBN 978-3-642-13173-8.
  2. Rohlf T, Junier I, Képès F. Evolution of spatially optimized gene networks. Proceedings of the Sophia Antipolis Spring School, (eds. Amar P, Képès F & Norris V)
    2011, p. 75-90 (EDP Sciences). ISBN 978-2-7598-0644-7.
  3. Elati M, Rouveirol C. 
Unsupervised Learning for Gene Regulation Network Inference from Expression Data: A Review. 
In Algorithms in Computational Molecular Biology: Techniques, Approaches and Applications, (Eds Elloumi M and Zomaya AY) Jan 2011,  John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9780470892107.ch41.
Location - contact


5 rue Henri Desbruères
Genopole Campus 1, Bât. 6

contact (at)

Phone: +33(0)1 69 47 44 30
Fax: +33(0)1 69 47 44 37


To visit us, please follow Genopole access indications.  Once on Genopole campus 1, iSSB is located on the first floor of Building 6, which is the first building to your left as you cross the pedestrian gate, or to your right as you cross the car gate.


Longitude: E 2° 27' 4''
Latitude: N 48° 37' 7''



   Congratulations to the iGEM-Evry 2018 team that was nominated for the "best composite part" price, and that won a Gold Medal at the final world iGEM jamboree. To follow their work, please visit their wiki.


 The annual spring School on advances in Systems and Synthetic Biology (aSSB) becomes an autumn School, on November 18-22, 2019.

 iSSB is pleased to announce the creation of the spin-off Synovance, founded by two former iSSB researchers.

 The spin-off of iSSB Inovactis, founded by two former mSSB students, won the national competition I-Lab 2017 organized each year by the Ministry of Higher Education and Research to encourage the most innovative technologies.

  Based on publications in synthetic biology, an independent study (Nov 2015) found that iSSB ranks 3rd lab in Europe and 9th in the world, despite a comparatively small size.