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A primer on the institute of Systems & Synthetic Biology (iSSB)


  • iSSB was created in 2008 on the foundations of the Epigenomics Project, a Genopole network with a nation-wide reach, dedicated to systems biology since 1999, and to synthetic biology (SynBio) since 2005.
  • iSSB had incorporated four teams in four years:
Start-present            François KEPES
2007-2014                Nicolas POLLET
2008-present            Alfonso JARAMILLO
2009-present            Jean-Loup FAULON
2010-present            Piet HERDEWIJN & Philippe MARLIÈRE
  • iSSB was the first laboratory dedicated to SynBio in Europe, together with IoSSB at Imperial College London.



  • iSSB is the sole French laboratory entirely dedicated to SynBio.
  • iSSB currently hosts 43 staff including 34 researchers.
  • iSSB raises competitive funds at exceptional levels.
  • iSSB ranks 3rd lab in Europe and 9th worldwide for SynBio publications.


  • iSSB aims at contributing to the framework of concepts and methods that constitutes the core of SynBio.
  • iSSB aims at growing its local SynBio "ecosystem" of education tracks, academic teams, technological platform, and spin-off and other small companies.
  • iSSB aims at diffusing SynBio in France and abroad.



iSSB is a laboratory belonging to the UMR 8030 mixed research unit of University of Évry-Val-d'EssonneUniversity Paris-Saclay, CEA and CNRS.

It includes four teams active in the fields of xeno-nucleic acids and synthetic genomics, and of synthetic biochemical circuits. Their acronyms are XenomeMEGASynth-Bio and Bio-Retrosynth.

Download iSSB flyer here.

Location - contact


5 rue Henri Desbruères
Genopole Campus 1, Bât. 6

contact (at)

Phone: +33(0)1 69 47 44 30
Fax: +33(0)1 69 47 44 37


To visit us, please follow Genopole access indications.  Once on Genopole campus 1, iSSB is located on the first floor of Building 6, which is the first building to your left as you cross the pedestrian gate, or to your right as you cross the car gate.


Longitude: E 2° 27' 4''
Latitude: N 48° 37' 7''



Symposium BioSynSys 2017. 3rd symposium of the GDR "Biologie de Synthèse et des Systèmes", 18 - 20 October, 2017, in Montpellier (France).

  Based on publications in synthetic biology, an independent study (Nov 2015) found that iSSB ranks 3rd lab in Europe and 9th in the world, despite a comparatively small size. 

 iSSB is pleased to announce the creation of the spin-off Inovactis, founded by two former mSSB students. 

  The European Experience 2016!  The teams iGEM Evry and iGEM IONIS have organized together a thrilling meeting week-end, gathering students from all Europe.