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A primer on the institute of Systems & Synthetic Biology (iSSB)


  • iSSB was created in 2008 on the foundations of the Epigenomics Project, a Genopole network with a nation-wide reach, dedicated to systems biology since 1999, and to synthetic biology (SynBio) since 2005.
  • iSSB had incorporated six teams:

Start-present            François KEPES
2007-2014                Nicolas POLLET
2008-present            Alfonso JARAMILLO
2009-present            Jean-Loup FAULON
2010-present            Piet HERDEWIJN & Philippe MARLIÈRE

2017-present            Mohamed ELATI

  • iSSB was the first laboratory dedicated to SynBio in Europe, together with IoSSB at Imperial College London.



  • iSSB is the sole French laboratory entirely dedicated to SynBio.
  • iSSB raises competitive funds at exceptional levels.
  • iSSB ranks 3rd lab in Europe and 9th worldwide for SynBio publications (2015).


  • iSSB aims at contributing to the framework of concepts and methods that constitutes the core of SynBio.
  • iSSB aims at growing its local SynBio "ecosystem" of education tracks, academic teams, technological platform, and spin-off and other small companies.
  • iSSB aims at diffusing SynBio in France and abroad.



iSSB is a laboratory belonging to the UMR 8030 mixed research unit of University of Évry-Val-d'EssonneUniversity Paris-Saclay, CEA and CNRS.

It includes five teams active in the fields of xeno-nucleic acids and synthetic genomics, and of synthetic biochemical circuits. Their acronyms are XenomeASG, I3-BioNetSynth-Bio and Bio-Retrosynth.

Download iSSB flyer here.

Location - contact


5 rue Henri Desbruères
Genopole Campus 1, Bât. 6

contact (at)

Phone: +33(0)1 69 47 44 30
Fax: +33(0)1 69 47 44 37


To visit us, please follow Genopole access indications.  Once on Genopole campus 1, iSSB is located on the first floor of Building 6, which is the first building to your left as you cross the pedestrian gate, or to your right as you cross the car gate.


Longitude: E 2° 27' 4''
Latitude: N 48° 37' 7''



 GDR Biosynsys 2018, Toulouse, October 21-24, 2018. Registrations are open


 iSSB is pleased to announce the creation of the spin-off Synovance, founded by two former iSSB researchers.

Congratulations to the iGEM 2017 team "Evry-Paris Saclay" that won a Gold Medal at the final world iGEM jamboree. To follow their work, please visit their wiki.

 The spin-off of iSSB Inovactis, founded by two former mSSB students, won the national competition I-Lab 2017 organized each year by the Ministry of Higher Education and Research to encourage the most innovative technologies.

  Based on publications in synthetic biology, an independent study (Nov 2015) found that iSSB ranks 3rd lab in Europe and 9th in the world, despite a comparatively small size.